In Mar 1586 a virulent outbreak of gaol fever occurred during the Assizes in Exeter, Devon [Map]. The cause according to modern medical opinion was typhus transmitted by the human body-louse. Among the dead victims were eight judges, eleven of the twelve jurors, several constables, and the surrounding population which was ravaged by the disease for several months.

Edward Flowerdew died of gaol fever.

On 28 Mar 1586 Thomas Carew of Haccombe (age 70) died of gaol fever.

On 31 Mar 1586 John Chichester died of gaol fever.

On 01 Apr 1586 Robert Carey (age 71) died of gaol fever.

On 02 Apr 1586 Arthur Bassett (age 45) died of gaol fever.

On 10 Apr 1586 Bernard Drake (age 58) died of gaol fever.