On 15 May 1567 James "Lord Bothwell" Hepburn 1st Duke Orkney (age 33) and Mary Queen of Scots (age 24) were married in the Great Hall Holyrood House. She the daughter of King James V of Scotland and Mary of Guise Queen Consort Scotland. He the son of Patrick Hepburn 3rd Earl Bothwell and Agnes Sinclair Countess Bothwell. They were half third cousin once removed. He a great x 5 grandson of King Edward III of England. She a great granddaughter of King Henry VII of England and Ireland.