COI 18.75% and Higher is in Coefficient of Inbreeding.
On 12th August 1573 Charles Laurence Habsburg Spain was born to Philip "The Prudent" II King Spain [aged 46] and Anna of Austria Queen Consort Spain [aged 23]. Coefficient of inbreeding 21.27%. He died aged one in 1575.
On 3rd April 1578 Philip III King Spain was born to Philip "The Prudent" II King Spain [aged 50] and Anna of Austria Queen Consort Spain [aged 28]. Coefficient of inbreeding 21.27%. He married 18th April 1599 his first cousin once removed Margaret of Austria Queen Consort Spain and had issue.
On 15th August 1575 Diego Prince of Asturias was born to Philip "The Prudent" II King Spain [aged 48] and Anna of Austria Queen Consort Spain [aged 25]. Coefficient of inbreeding 21.27%. He died aged seven in 1582.
On 4th December 1571 Ferdinand King Asturias was born to Philip "The Prudent" II King Spain [aged 44] and Anna of Austria Queen Consort Spain [aged 22]. Coefficient of inbreeding 21.27%. He died aged six in 1578.
On 14th February 1580 Maria Habsburg Spain was born to Philip "The Prudent" II King Spain [aged 52] and Anna of Austria Queen Consort Spain [aged 30]. Coefficient of inbreeding 21.27%. He died aged three in 1583.
On 20th January 1554 Sebastian King Portugal was born to John Manuel Aviz Prince Portugal [deceased] and Joanna of Austria Princess Portugal [aged 18]. He was named after Saint Sebastian on whose Feast Day he was born. At birth he was heir apparent to the throne of Portugal since his father had died two weeks before his birth. Soon after his birth his mother Joanna of Austria Princess Portugal left Portugal to become Regent of Spain for her father serving in the same capacity for her brother after her father's abdication. She never saw him. Coefficient of inbreeding 20.02%.
On 8th July 1545 Carlos Prince of Asturias was born to Philip "The Prudent" II King Spain [aged 18] and Princess Maria of Portugal [aged 17]. Coefficient of inbreeding 20.02%.
On 26th April 1822 Princess Maria of the Two Sicilies was born to Leopold Prince of Salerno [aged 31] and Archduchess Clementina of Austria [aged 24]. Coefficient of inbreeding 19.79%. She married 25th November 1844 her fourth cousin once removed Prince Henri Duke of Aumale.
On 10th October 1830 Isabella II Queen Spain was born to Ferdinand VII King Spain [aged 45] and Maria Christina of the Two Sicilies Queen Consort Spain [aged 24]. Coefficient of inbreeding 19.31%. She married her first cousin Francisco de Asís King Consort Spain and had issue.
In 1638 Maximilian Philipp Hieronymus Wittelsbach Duke Leuchtenberg was born to Maximilian "The Great" Wittelsbach I Duke Bavaria I Elector Bavaria [aged 64] and Maria Anna Habsburg Spain Duchess Bavaria [aged 27]. Coefficient of inbreeding 19.28%. He married 1668 Maurita Febronia de La Tour d Auvergne.
In 1636 Ferdinand Maria Wittelsbach was born to Maximilian "The Great" Wittelsbach I Duke Bavaria I Elector Bavaria [aged 62] and Maria Anna Habsburg Spain Duchess Bavaria [aged 25]. Coefficient of inbreeding 19.28%. He married 1652 Henriette Adelaide Savoy and had issue.