On 14 Feb 1580 Maria Habsburg Spain was born to Philip "The Prudent" II King Spain (age 52) and Anna of Austria Queen Consort Spain (age 30). Coefficient of inbreeding 21.27%.

On 04 Dec 1571 Ferdinand King Asturias was born to Philip "The Prudent" II King Spain (age 44) and Anna of Austria Queen Consort Spain (age 22). Coefficient of inbreeding 21.27%.

On 12 Aug 1573 Charles Laurence Habsburg Spain was born to Philip "The Prudent" II King Spain (age 46) and Anna of Austria Queen Consort Spain (age 23). Coefficient of inbreeding 21.27%.

On 03 Apr 1578 Philip III King Spain was born to Philip "The Prudent" II King Spain (age 50) and Anna of Austria Queen Consort Spain (age 28). Coefficient of inbreeding 21.27%.

On 15 Aug 1575 Diego King Asturias was born to Philip "The Prudent" II King Spain (age 48) and Anna of Austria Queen Consort Spain (age 25). Coefficient of inbreeding 21.27%.

On 20 Jan 1554 Sebastian King Portugal was born to John Manuel Aviz Prince Portugal (deceased) and Joanna of Austria Princess Portugal (age 18). He was named after Saint Sebastian on whose Feast Day he was born. At birth he was heir apparent to the throne of Portugal since his father had died two weeks before his birth. Soon after his birth his mother Joanna of Austria Princess Portugal (age 18) left Portugal to become Regent of Spain for her father serving in the same capacity for her brother after her father's abdication. She never saw him. Coefficient of inbreeding 20.02%.

On 08 Jul 1545 Carlos Habsburg Spain was born to Philip "The Prudent" II King Spain (age 18) and Maria Aviz (age 17). Coefficient of inbreeding 20.02%.

In 1638 Maximilian Philipp Hieronymus Wittelsbach Duke Leuchtenberg was born to Maximilian "The Great" Wittelsbach I Duke Bavaria I Elector Bavaria (age 64) and Maria Anna Habsburg Spain Duchess Bavaria (age 27). Coefficient of inbreeding 19.28%.

In 1636 Ferdinand Maria Wittelsbach was born to Maximilian "The Great" Wittelsbach I Duke Bavaria I Elector Bavaria (age 62) and Maria Anna Habsburg Spain Duchess Bavaria (age 25). Coefficient of inbreeding 19.28%.